HERPES and HIV (AIDS) RELATED RESEARCH

Ebina, et. al., 1983, The Lancet, Vol. 29 No 2 pp. 1029-1030: "Prevention of Rotavirus Infection By Cow Colostrum Containing Antibody Against Human Rotavirus": Japanese researchers exposed cattle to oral doses of rotavirus which causes severe diarrhea and bowel inflammation in humans. Colostrum from these cows contained antibodies which, when fed to humans, prevented them from getting rotavirus.

Stephan, Dichtelmuller and Lissner, 1989, Journal of Clinical Chem. and Clinical Biochem., Vol. 28, 1990, no 1: "Antibodies from Colostrum in Oral Immunotherapy": Spray dried concentration of immunoglobin preparation for oral use from pooled source of 100 cows was found to be highly effective in treatment of severe diarrhea e.g. in AIDS patients. After treatment no cryptosporidia were found in stools where it had been previously detected.

Foothill, Oak and Mott, 1990, Archives of Disease in Childhood, Vol. 65 p.p. 813-14: "Case Report": Favorable treatment of Cryptosporidiosis with pooled bovine colostrum via oral administration was reported

Nord, DiJohn, Tripori, Tacket, 1990, AIDS, Vol. 4(6) pp. 581-4: "Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients": Double Blind, controlled pilot study of hyperimmune colostrum in five aids patients by nastric infusion. Conclusion that treatment was effective. More studies suggested.

Ungar, Ward, Fayer and Quinn, 1990, Gastroenterology, Vol. 98 pp. 486-89: "Cessation of Cyptosporidium-Associated Diarrhea in an AIDS Patient after oral treatment with Hyperimmune Bovine Colostrum": Cryptosporidium absent after treatment.

Desert News, Salt Lake City, Utah June 19, 1991 Mentioned Study by protozoologist Ron Fayer US Dept. of Agric.: two AIDS patients with cryptosporidium caused diarrhea were relived of symptoms in treatment with hyperimmune colostrum. A larger study to continue at Johns Hopkins Hospital. Dr. Bruce Anderson a veterinary pathologist at the University of Idaho stated: "There have been over 50 drugs tried to relive AIDS patients diarrhea, they didn’t work. But this hyper immune colostrum does." Anderson is credited with suggesting this form of therapy because he noticed that a number of veterinary students would come down with cryptosporidiosis after contact with cattle who had disease. He theorized that immune capability could be transferred to humans.

Flanigan, Marshall, Redman, Kaetzel, Ungar, 1991) Journal. Protozool Nov-Dec, Vol. 38(6): 225s-227s A. Diarrhea producing Cryptosporidium parvum infection treated effectively with oral ingestion of bovine colostrum. B. Also effective in treatment of prophylaxis and rotavirus gastroenteritis C. Hyper immune cows colostrum and regular cows colostrum compared: Parasite infections reduces 82% in presence of hyperimmune and 67% in regular colostrum."

Immunoglobulin to Prevent Nosocomial Infections, New England Journal of Medicine, July 23, 1992, Vol. 327 No 4 p 269. Immunoglobulin from bovine colostrum effective in reducing and preventing infections in immune deficient subject: bone marrow recipients, premature babies, AIDS, etc. Problem: obtaining high and consistent levels of functional antibodies though donor selection. Could improve through pooled selection, selective donor immunization.

Jage, Kampmann, Kolb, et. al., 1992, Clin. Investigation Jul.; 70(7): 588-94 Reported: A. Immunoglobulins from bovine colostrum (lactobin, biotest, Dreieich, FRG) contain high titres of antibodies against a wide range of bacterial, viral and protozoa pathogens, as well as against various bacterial toxins. B. Lactobin quite resistant to gastric acids. C. Effective in the treatment of opportunistic infections that cause diarrhea. Treatment and effectiveness in AIDS patients verified, where no other treatment was effective.

Rump, et. al., 1992, Clinical Investigator, Vol. 70 pp. 588-94: Treatment of Diarrhea in AIDS and bone marrow transplant patients with Bovine Colostrum: Reported colostrum quite resistant to gastric juice. Oral treatments very effective. No side effects.

Plettenberg, et. al., 1993, Clinical Investigator, Vol. 71 p.p. 42-45: Open study of 25 AIDS patients with cryptospoidiosis were treated with a daily oral dose of 10g of bovine colostrum for 10 day period. Complete remission reported in 40% and a partial remission in 24% of patients described. Treatment is judged overall: effective.

New Scientist, Jan 8, 1994: Reported an Australian Co. has been involved in successful human trials with an oral administration of over 500 patients in hospitals in India, Hong Kong and Australia with hyperimmune colostrum specific for rotavirus a diarrhea causing virus rampant in third world countries but common in developed countries also.

Rouse, B.T. et.al., 1976, Infection and Immunity, 13, pp. 1433. Antibody-dependent Cell-Mediated Cytoxtoxicity in Cows: Comparison of Effector Cell Activity Against Heterologous Erthrocyte and Herpes-Virus-Infected Bovine Target Cells: "Bovine leukocytes have antibody dependent cell-mediated cytoxciity against bovine herpesvirus." Bovine Colostral cells with antibody were able to kill cells infected with herpes simplex in vivo.

Kohl,S. et.al., 1978, Journal of Clinical Laboratory Immunology, 1, pp. 221-224. "Human Colostral Cytotoxicity: Antibody-Dependent Cellular Cytotoxicity Against Herpes Simplex-Infected Cells Mediated by Colostral Cells ": Colostral cells along with antibody were found to destroy herpes simplex-infected cells.

Raloff, Science News, Apr 15, 1995 Vol 147 p231(1) More Ways Mother’s milk fights disease: Contains Retinoic Acid which helps baby fight herpesvirus. The glycoprotein kappa casein protects against H. Pylori bacteria that causes stomach ulcers, (Ratinoic acid and kappa casein found in bovine colostrum also).

Isaacs, et. al.,1995, Science, April p.p. 231: "Reporting in Experimental Biology "95: teams confirmed colostrum delivers not just antibodies but a battery of infection fighting agents. Among them, retinoic acids a Vitamin A derivative. Dr. Charles E. Isaacs et. al. at New York State Institute for Basic Research on Staten Island, NY, infected culture cells with herpesvirus, his findings were that only retinoic acids conferred protection and reduced colonization. He concluded that while ratinoic acids were not a cure, it effectively reduced the herpes virus to levels ( 1/100 to 1/10,000 viruses remained active after treatment ) where the bodies immune system could fight off an outbreak.

Harmsen, et al.,Jour. Infectious Disease 1995 V. 172 p 380-8 Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus HIV and human cytomeglavirus HCMV in vitro: "Only native and conformationally intact Lactoferrin from bovine colostrum or human milk could completely block Cytomegalovirus infection. Moreover, native Lactoferrin also inhibited the HIV-1 induced cytopathic effect. When negatively charged groups were added to Lactoferrin by succinylation there was a 4-fold increased anti-viral effect on HIV. Lactoferrin likely exerts its effect at the level of virus absorption or penetration (or both), because after cytomegavirus penetrated cellular tissue the ongoing infection could not be further inhibited.

Fisher, Jeffery, 1994, Futurist Nov-Dec: "Book Review; "The Plague Makers" Simon And Schuster, NY "Antibiotics taken in successive and prolonged doses may suppress the immune system enough to allow unusual forms of mycoplasma bacteria to develop. These bacteria interact with HIV to form AIDS. Antibiotics act as catalyst for the process. Warns against the reliance on antibiotics. Suggests alternative means to stimulate immune response.

Deseret News, SLC, Utah, Apr 6, 1995: Component of Human Milk Blocks HIV infection: "Research reported in the March issue of the Journal Of Nutrition by David Newburg of the Harvard Medical School, reported a component called chondroitin sulfate blocks the binding of HIV to its host cell receptor. This could limit the postnatal transmission of HIV in breast fed infants of HIV infected mothers.

Nowa, McMichael, Scientific American Aug 1995 p58-65. How HIV defeats the immune System: " Continuous and dangerous evolution of HIV virus underlies body and medical sciences inability to find means to defeat. Vaccines not effective, virus mutates too quickly and there are too many mutant variations. Reducing viral levels in the body and stimulating natural immune capabilities have the most promise to help natural immune system contain the virus.