RESEARCH RELATED TO
Human studies with bovine colostrum
O = Studies directly related to bovine
Wada et. al., 1980, Infection and Immunity, 29,
pp 545-550. "Neutralizing Activity Against Clostridium Difficile
Toxins in the Supernatants of Cultured Colostral Cells": Colostrum
immune factors neutralize crude toxins
Paulik, et. al., 1985, Veterinari Medicina,
Poland, Vol. 30 No 1 pp. 21-28: " Lysozyme in the Colostrum and Blood
of Calves of Diary Cows": Lysoszyme in bovine (and human)
colostrum is the enzyme present in egg white, tears, saliva and
other body fluids that kills bacteria by dissolving their cell walls.
Tokuyama and Tokuyama, 1989, Dept. of Molecular
Immunology, Cancer Research Institute and Dept. of Nuclear Medicine,
Kananawa University, Kanaawa, Japan. Harwood Academic Publishers, UK. Cellular
Biology Report 13, 251-258; "Bovine Colostric Transforming
Growth Factor-B-Like peptide induces growth inhibition and changes
morphology of human osteogenic sarcoma (cancer) cells": TgF B
produced cell destruction in certain human cancer (sarcoma) cells in cell
culture growth experiments in Japan.
Tokuyama, et. al., 1990, Dept. of Molecular Immunology,
Cancer Research Institute and Dept. of Nuclear Medicine, Kananawa
University, Kanaawa, Japan. Harwood Academic Publishers, UK: Reported
two new Proteins discovered in Bovine Colostrum: BC-1 and BC-2. Belong to
a new class of mitogen inhibitors. Reported that through biological
activities resemble TGF-B. Showed inhibitory effect on some sarcoma
(cancer) tumor cell lines in sutro.
Dillehay, Dirck L. American Institute of Nutrition.
1994. Biochemical and Molecular Roles of Nutrients. Dietary Sphingomyelin
(Found in bovine colostrum and milk) Inhibits
1,2-Dimethylhydrazine-Induced Colon Cancer in CF1 Mice1-4. Sphingomyelin
significantly reduced evidence of colon cancer.
Parodi, PW. The Australian Journal of Dairy
Technology, Vol. 51, April 1996. Bovine milk fat components: possible
chemopreventive agents for cancer and other diseases. Evidence suggests
that bovine milk fat contains cancer fighting components.
Neely, EK, et al, Dept. of Ped., Stanford Univ. Sch. Of
Med., Calif., J. Invest. Dermatol., 1991. "Insulin-like
growth factors are mitogenic for human keratinocytes and a squamous cell
Moro, et. al., 1985, Cellular Immunology, 93(2)
pp. 467-74: "Natural Killer Cells in Human Colostrum":
Approximately 0.5% of colostral cells were identified as natural killer
cells of two morphological types.
Tokuyama and Tokuyama, 1993, Jour.Dairy Res. Vol
60: 99-109 (Printed in Great Britain) Bovine colostrum contains high
levels of transforming growth factor (TGF) - beta-like activity during the
first 12 – 30 hours after parturition. Results of study indicate that
TGF-beta-like growth factor found in bovine colostrum is chemically and
antigenically related to TGF-beta2.
Hakansson, et. al., Proceedings, the Nation Academy
of the Sciences, Vol 92, pp. 8064-8068 Aug. 1995, Research Study: Lund
University, Stockholm, Sweden. Study showed in vitro effect of ingredient
in human milk and colostrum: multimeric a-lactalbumin caused lung cancer
(transformed epithelial cells) to create selective suicide. (apatosis).
Normal surrounding cells unaffected. Conclusion: multimeric a-lactalbumin
- is a potent Ca2+ -elevating and apoptosis-inducing agent with broad, yet
selective, cytoxic activity.
Business Week, Feb. 6, 1995: "Quiet Strides
in the War on Cancer": National Cancer Institute researcher Steven A.
Rosenberg became a media sensation when he achieved success with cancer
patients in 1985 using an experimental technique called immunotherapy.
Since cancers can invade the immune system, why not load the body with
killer immune cells, along with special chemical messengers called
Cytokines that give the body an extra kick." Treatments partially
successful. More trials ongoing. Cytokine for cancer vaccines is the
largest single protocol under study today.
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